Prognostic Factors in Cancer, Third Edition is divided into two parts. A few studies that have been done in Uganda on survival of patients with prostate cancer indicate that, the overall survival of patients with prostate cancer in Uganda is poor. M. K. Gospodarowicz, P. Hermanek, and D. E. Henson Attention to innovations in cancer treatment has tended to eclipse the importance of prognostic assessment. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. When normal … Some of the factors that affect prognosis include: The type of cancer and where it is in your body The stage of the cancer, which refers to the size of the cancer and if it has spread to other parts of your body The cancer’s grade, which refers to how abnormal the cancer cells look under a microscope. Men with TNM stage I to stage III breast cancer diagnosed between 2004 and 2014 in the National Cancer Data Base were included. Prognostic factors of pancreatic cancer survival. The rate of pulmonary metastasectomy from colorectal cancer (CRC) has increased with recent advances in chemotherapy, diagnostic techniques, and surgical procedures. Faris M: Clinical estimation of survival and impact of other prognostic factors on terminally ill cancer patients in Oman. This study was a retrospective, single-institution study … independent prognostic factors. Multivariate analysis was used to identify the independent prognostic factors. A woman who lives to age 90 has a one in eight chance of developing breast cancer. Prognostic factors. Reviewing studies from the literature performed using univariate and multivariate analyses and their own study, the authors critically discuss the prognostic value of the clinicopathologic parameters of the tumor. The text is an extension of the International Union Against Cancer's (UICC) seminal work, the TNM Classification of Malignant Tumours, and integrates the current focus on prognostics in cancer. These factors … The outcome in patients with cancer is determined by a combination of numerous factors. Pinder SE, Ellis IO, Galea M, et al. Cancer science. J Clin Oncol 2008; 26:3153. To comprehensively represent these factors we propose three broad groupings of prognostic factors: ‘tumor’‐related prognostic factors, ‘host’‐related prognostic factors, and ‘environment’‐related prognostic factors. To compare the prognostic value of the sixth and seventh editions of the TNM classification, and of additional prognostic factors, in colorectal cancer. The only factors predictive of low 1-year OS were TPS elevated and staging laparotomy. There are no key documents associated with this page. In 2008, the number of incident cases was estimated to be around 1.6 million (13% of all incident cancers). Learn more. Histopathology 1989; 14:613. Recent studies have shown that angiogenesis is a potent prognostic indicator for patients with prostate cancer and that the evaluation of endothelial growth factors is useful in assessing the angiogenic phenotype in prostate cancer. However, the prognostic accuracy can be significantly … Mortality is high with 1.4 million of deaths the same year (18% of all deaths from cancer) (www.globocan.iarc.fr). A prognostic factor is a factor associated with disease-free or overall survival in the absence of systemic adjuvant therapy. 43.31; U.S. Department of Veterans Affairs; Jeffrey D Seidman. The CSS was 134.36 ± 1.71 months for patients over 45 years of age, and 141.59 ± 1.23 months for patients under 45 years of age, suggesting that age ≥ 45 was an independent prognostic factor (hazard ratio [HR] = 3.595, 95% confidence interval: 1.415–9.131). Prognostic Factors in Cancer, Third Edition examines the prognostic factors associated with each cancer site and provides insight into potential treatments and therapies. Most prognostic factors literature describes those factors that directly relate to the tumor itself. Viganò A, Bruera E, Jhangri GS, et al: Clinical survival predictors in patients with advanced cancer. Working off-campus? Factors in category III included DNA ploidy analysis, microvessel density, epidermal growth factor receptor, transforming growth factor-alpha, bcl-2, pS2, and cathepsin D. This report constitutes a detailed outline of the findings and recommendations of the consensus conference group, organized according to structural guidelines as defined. Independent factors predictive of low 2-year OS by multivariate analysis were staging laparotomy, TPS elevated, and CA 125 elevated. … and you may need to create a new Wiley Online Library account. Ann Surg Oncol 2012; 19:1944. Prognostic factors in cancer by , 2001, Wiley-Liss edition, in English - 2nd ed. The multivariate analysis showed that curability, GOO, the tumor size, lymph node metastasis, and the depth of invasion were independent prognostic factors. If you have previously obtained access with your personal account, please log in. Background. Rakha EA, El-Sayed ME, Lee AH, et al. Mortality is high with 1.4 million of deaths the same year (18% of all deaths from cancer) (www.globocan.iarc.fr). Are you interested in joining a dynamic network of over 1,000 members that share a passion to eliminate cancer as a life-threatening disease for future generations. Objectives: Ovarian cancer is the second most common gynecological cancer, and has a 5-year survival rate of about 40% to 45%. Most prognostic factors literature describes those factors that directly relate to the tumor itself. 1 Department of Obstetrics and Gynecology, Spedali Civili di Brescia, Italy. However, many other factors, not directly related to the tumor, also affect the outcome. However, the recognition that prognostic factors often have a greater impact on outcome than available therapies and the proliferation of biochemical, molecular, and genetic markers have resulted in renewed interest in this field. To plan the management of an individual cancer patient, the fundamental knowledge base includes the site of origin of the cancer, its morphologic type, and the prognostic factors specific to that particular patient and cancer. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Learn about our remote access options, Department of Radiation Oncology, University of Toronto, Princess Margaret Hospital, University Health Network. Macrometastases (>0.2 cm in size) have clearly been shown to … Doctors use different prognostic and predictive factors for newly diagnosed and recurrent breast cancers. Prognostic factors are quantifiable data that provide information regarding the expected outcome for patients with a particular disease prior to therapy. To guide the use of various prognostic factors we have proposed a grouping of factors based on their relevance in everyday practice; these comprise ‘essential,’ ‘additional,’ and ‘new and promising factors.’ The availability of a comprehensive classification of prognostic factors assures an ordered and deliberate approach to the subject and provide safeguard against skewed approaches that may ignore large parts of the field. Some prognostic factors are essential to decisions about the goals and choice treatment, while others are less relevant for these purposes. The current attention to tumor factors has diminished the importance of ‘patient’ (i.e., ‘host’), and almost completely overshadows the importance of the ‘environment’. Prognostic factors in early-stage ovarian cancer. Its overarching goal: major reductions in premature deaths from cancer, and improvements in quality of life and cancer survival rates. However, many other factors, not directly related to the tumor, also affect the outcome. 7 At first, vascular density was assessed by staining endothelial cells in prostate tissue sections with antibodies specific to factor VIII related antigen. Breast cancer treatment success depends upon prolonging survival with effective treatment, and constant monitoring of recurrence. Reviewing studies from the literature performed using univariate and multivariate analyses and their own study, the authors critically discuss the prognostic value of the clinicopathologic parameters of the tumor. If you do not receive an email within 10 minutes, your email address may not be registered, The following are prognostic and predictive factors for breast cancer when it is first found and diagnosed. Hutter,Leslie H. Sobin Publié le 2012-12-06 par Springer Science & Business Media. The text is an extension of the International Union Against Cancer's (UICC) seminal work, the TNM Classification of Malignant Tumours, and integrates the current focus on prognostics in cancer. Importance of Prognostic Factors Prognostic factors in cancer often have an immense influence on outcome, while treatment often has a much weaker effect. Recent studies have shown that angiogenesis is a potent prognostic indicator for patients with prostate cancer and that the evaluation of endothelial growth factors is useful in assessing the angiogenic phenotype in prostate cancer. Biomarkers of systemic inflammation may have prognostic value in advanced cancer. It hosts selected resources on cancer control like toolkits, multimedia campaigns or background data. Support Care Cancer 11:: 30, 2003-34, Medline, Google Scholar: 17. Germana Tognon 1, Mario Carnazza 1, Monica Ragnoli 1, Stefano Calza 1, 2, Federico Ferrari 1, Angela Gambino 1, Valentina Zizioli 1, Sara Notaro 1, Benedetta Sostegni 1 and Enrico Sartori 1. 21:13–18, 2003. We also investigated various other prognostic factors described in the literature. Prognostic Factors in Cancer: Gospodarowicz, Mary K, O'Sullivan, Brian, Sobin, Leslie H: Amazon.com.mx: Libros Available for purchase: John Wiley & Sons, Hoboken, New Jersey, USA. Achetez neuf ou d'occasion Histopathology 1991; 19:403. Importance of Prognostic Factors Prognostic factors in cancer often have an immense influence on outcome, while treatment often has a much weaker effect. Male breast cancer (MBC) is a rare disease for which there is limited understanding of treatment patterns and prognostic factors. Stage. One of the most important prognostic factors in cancer is the anatomic disease extent that routinely is classified according to the TNM classification. Encuentra Prognostic Factors in Cancer de Paul Hermanek (ISBN: 9780387586885) en Amazon. The stage is the main prognostic factor for breast cancer. Newly diagnosed breast cancer. Virtual Dialogues provide members with enhanced opportunities to connect, exchange knowledge, access expert insights, and more. After adjustment for all potential confounders and risk factors, rural inhabitance (HR: 1.33, 95%CI: 1.01–1.74), having more symptoms at diagnosis (HR for each increase in the number of symptoms: 1.06, 95%CI: 1.02–1.11), current opium use (HR: 1.51, 95%CI: 1.04–2.20), having a tumor that is located in the body of pancreas (HR: 1.33, … Histopathology 1991; 19:403. Prognostic factors in organ confined prostate cancer will reflect survival after surgical radical prostatectomy. © 2003 Wiley‐Liss, Inc. Amends and streamlines the authoritative monograph on prognostic factors and their use in planning treatment for cancer patients. In gynecologic oncology, valid prognostic factors are necessary to define biologically similar subgroups for analysis of therapeutic efficacy. [3] In addition to stage, doctors use other prognostic factors to help plan the best treatment and predict how well this treatment will work. Noté /5: Achetez Prognostic Factors in Cancer de Hermanek, Paul: ISBN: 9780387586885 sur amazon.fr, des millions de livres livrés chez vous en 1 jour Join us today: Through our proven track record of success, UICC is able to bring influential stakeholders together, and we invite you to be part of this journey and help us drive change globally. This ignores the fact that the latter presents the greatest potential for immediate impact. There are now a panoply of prognostic factors that can be assessed in CLL, and it is vital that these be assessed in clinical trials so that we can determine whether all CLL subgroups respond equivalently, and whether there is evidence that alterations in treatment are able to overcome the effects of adverse prognostic factors. View the article PDF and any associated supplements and figures for a period of 48 hours. Semin. Use the link below to share a full-text version of this article with your friends and colleagues. Background . Noté /5. NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. PURPOSE: Identification of prognostic factors is a primary basis for planning the treatment and predicting the outcome of patients with colorectal cancer. During the past two decades many studies to evaluate the prognostic parameters of endometrial cancer have been per-formed. Gastric cancer with GOO exhibits aggressive biological features and has poor outcomes. Diagnosis, prognosis, and treatment are the three core elements of the art of medicine. Materials and Methods. Purpose: In advanced cancer, oncological treatment is influenced by performance status (PS); however, this has limitations. The most significant prognostic factor in breast cancer is the presence or absence of axillary lymph node involvement, 4 which is usually assessed at the time of surgery using sentinel lymph node biopsy or axillary dissection. Prognostic Factors in Cancer, Third Edition examines the prognostic factors associated with each cancer site and provides insight into potential treatments and therapies. Prognostic factors in colonic cancer. Survival rate can well be improved by better understanding of prognostic factors, preventive measures, and effective treatments together with follow-up and post-treatment care.This study is aimed to know prognostic factors effective in recurrence … View 0 peer reviews of Prognostic factors for progression-free and overall survival in advanced biliary tract cancer on Publons COVID-19 : add an open review or score for a COVID-19 paper now to ensure the latest research gets the extra scrutiny it needs. Germana Tognon 1, Mario Carnazza 1, Monica Ragnoli 1, Stefano Calza 1, 2, Federico Ferrari 1, Angela Gambino 1, Valentina Zizioli 1, Sara Notaro 1, Benedetta Sostegni 1 and Enrico Sartori 1. Envíos gratis a partir de 19€. 2. For example, the influence of the presence of lymph node involvement on survival of patients with metastatic breast cancer is much greater than the effect of adjuvant treatment with tamoxifen in the same group of patients [5]. Aim: Study the prognostic factors in non small-cell lung cancer. The acceptance of a generic prognostic factor classification would facilitate communication and education about this most important subject in oncology. Surg. Pathological prognostic factors in breast cancer. Male breast cancer (MBC) is a rare disease for which there is limited understanding of treatment patterns and prognostic factors. Thus, the present study is aimed at investigating the influence of T stage on the predictive value of tumor size in clinical stage I–IV esophageal cancer patients. Differential prognostic factors were identified for patients with low- and high-burden metastatic prostate cancer. The second part consists of site-specific or tumour-specific chapters and the prognostic factors associated with particular malignancies. Tumor size has been measured in esophageal cancer for decades, but the role of tumor size in relation to T stage in the prediction of survival is still underappreciated. Retrouvez Prognostic Factors in Cancer et des millions de livres en stock sur Amazon.fr. Oncol. In breast cancer, a number of factors are considered truly … Tumour subtype has a significant effect on bone metastasis in breast cancer, but population-based estimates of the prognosis of patients with bone metastases at breast cancer diagnosis are lacking. Purpose: In advanced cancer, oncological treatment is influenced by performance status (PS); however, this has limitations. Prognostic significance of Nottingham histologic grade in invasive breast carcinoma. Background.—Under the auspices of the College of American Pathologists, a multidisciplinary group of clinicians, pathologists, and statisticians considered prognostic and predictive factors in prostate cancer and stratified them into categories reflecting the strength of published evidence and taking into account the expert opinions of the Prostate Working Group members. Doctors use different prognostic and predictive factors for newly diagnosed and recurrent breast cancers. Children whose cancer does not respond as well may be given more intensive chemotherapy. Conclusions: Ovarian cancer patients with elevated CA 125 levels after three chemotherapy courses have a poor prognosis. Pathological prognostic factors in breast cancer. Predicts recovery from cancer without additional or adjuvant systemic therapy after initial surgery. This ratio ranges from 15% to 95%, based on prognostic factors . However, many other factors, not directly related to the tumor, also affect the outcome. Prognostic value of tumor "budding" in patients with colorectal cancer. The most significant prognostic factor in breast cancer is the presence or absence of axillary lymph node involvement,4which is usually assessed at the time of surgery using sentinel lymph node biopsy or axillary dissection. For example, the influence of the presence of lymph node involvement on survival of patients with metastatic breast cancer is much greater than the effect of adjuvant treatment with tamoxifen in the same group of patients [5]. Modern medicine pays more attention to diagnosis and treatment but prognosis has been a part of the practice of medicine much longer than diagnosis. Prognostic significance of Nottingham histologic grade in invasive breast carcinoma. UICC Campaign Manager  Oncology; OBJECTIVE: Testicular cancer is a relatively rare neoplasia, with an incidence of about 1,5% among male malignancies, usually in the third and fourth decade of life. They both play a part in deciding on a treatment plan and a prognosis. The book imparts a perspective on likely outcomes of neoplastic disease that is an increasingly useful tool for physicians and all others responsible for the care of patients with cancer. Prognostic factors for children with AML Prognostic factors are not quite as important in predicting outcome or in guiding treatment for AML as they are for ALL. Biomarkers of systemic inflammation may have prognostic value in advanced cancer. I. NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. Prognostic factors in early-stage ovarian cancer. I. Macrometastases (>0.2 cm in size) have clearly been shown to … Methods . In demanding better standards for future research in the field of prognostic prediction – being able to tell patients what survival duration they can expect – the researchers hope that patients will be able to better adapt their lives to the impact of the cancer diagnosis on their survival. 6. Morikawa T, Kuchiba A, Qian ZR, et al. The first part provides an update on the science of prognosis in general and prognosis in cancer patients in particular. The ICCP Portal is a one-stop shop for cancer prevention and control planning. Prognostic and predictive factors are often discussed together. View Job description. Lung cancer is the most common cancer worldwide. Cancer is a heterogeneous group of disease characterized by growth, invasion and metastasis. Men with TNM stage I to stage III breast cancer diagnosed between 2004 and 2014 in the National Cancer Data Base were included. March 1997; Authors: Timothy J O'Leary. Prognostic Factors in Cancer Par:Paul Hermanek,Mary K. Gospodarowicz,Donald E. Henson,Robert V.P. These results may assist in decision-making to select the optimal therapeutic strategies for patients with different metastatic burdens. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Prognostic significance and molecular associations of tumor growth pattern in colorectal cancer. Lung cancer is the most common cancer worldwide. Prognostic factors in carcinoma breast 2. Importantly, though, these prognostic values provide information on a population level and may have only limited application to individuals within that population. There are numerous clinical, pathological and biological factors related to prognosis . Prognostic and Predictive Factors in Breast Cancer Kyle T. Bradley, MD, MS CAP Cancer Committee Breast cancer is the most common malignant tumor in American women and is second only to lung cancer as a cause of cancer-related mortality. Numerous prognostic and predictive factors for breast cancer have been identified by the College of American Pathologists (CAP) to guide the clinical management of … 2 Department of Molecular and Translational Medicine, University of Brescia, Italy However, no statistically significant association of OS and EFS was found with age, sex, time‐lapse before the start of treatment, and platelets count at the time of presentation. Conclusions. There are no related files associated with this page. The study compares key factors in prognosis (performance status, patient-reported outcomes; PRO) with an inflammation-based score (Glasgow Prognostic Score, mGPS). Please check your email for instructions on resetting your password. Predicts the likelihood of patient survival. Outstanding Contribution to Cancer Control Award, Integrated Cancer Control Initiative in Latin America (ICCI-LA), International Collaboration on Nutrition in relation to Cancer (ICONIC), On-line voting at UICC's first virtual General Assembly, 2020-2022 Board of Directors and President-elect candidates' profiles, Global Initiative for Cancer Registries (GICR), UICC responding to the call to action to eliminate cervical cancer, Members response to call to action to eliminate cervical cancer, Prognostic Factors in Cancer, 3rd edition. Carcinoma of breast is most common malignancy and is the leading cause of death in women. Most prognostic factors literature describes those factors that directly relate to the tumor itself. Although several histological variants are known, with some histotypes affecting older patients (e.g., spermatocytic seminoma), there is a clear predominance (90-95%) of germ cell tumors among young adults patients1. Gleason score, tumour volume, surgical margins and Ki-67 index have the most significant prognosticators. … 2020 Nov 07 [Epub ahead of print] To comprehensively represent these factors we propose three broad groupings of prognostic factors: 'tumor'-related prognostic factors, 'host'-related prognostic factors, and 'environment'-related prognostic factors. International Cancer Control Partnership (ICCP), About UICC - Leading the cancer community (Tri-fold leaflet), World Cancer Day 2020 International Public Opinion Survey on Cancer 2020, Editors: Mary K. Gospodarowicz, Brian O'Sullivan, Leslie H. Sobin. 8765845035,9305421547 Email: … Introduction : Lung cancer is one of the most frequently occurring neoplasms and usually has a poor prognosis because most of the patients present with advanced or metastatic disease at the time of diagnosis. Are you interested in joining a dynamic network of over 1,000 members that share a passion to eliminate cancer as a life-threatening disease for future generations. 5 PROGNOSTIC FACTORS Prognostic Factors are clinical, pathologic, and biological features of cancer patients and their tumors that forecast probable course and outcome of the disease. Prostate cancer is the second most common cancer among men globally. For people with Hodgkin lymphoma, several factors can predict whether the disease will return and which treatments will be successful. Prognostic Factors in Breast Cancer. PROGNOSTIC AND PREDICTIVE FACTORS FOR METASTATIC CARCINOMA BREAST 1. 150 prognostic factors pertaining to the tumor, to the patient, or to the environment. Prognostic factors in early-stage ovarian cancer Germana Tognon 1, Mario Carnazza , Monica Ragnoli , Stefano Calza1, 2, Federico Ferrari 1, Angela Gambino , Valentina Zizioli , Sara Notaro 1, Benedetta Sostegni and Enrico Sartori1 1 Department of Obstetrics and Gynecology, Spedali Civili di Brescia, Italy Unlimited viewing of the article PDF and any associated supplements and figures. Hase K, Shatney C, Johnson D, et al. The study compares key factors in prognosis (performance status, patient-reported outcomes; PRO) with an inflammation-based score (Glasgow Prognostic Score, mGPS). 2 Department of Molecular and Translational Medicine, University of Brescia, Italy The first part provides an update on the science of prognosis in general and prognosis in cancer patients in particular. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, I have read and accept the Wiley Online Library Terms and Conditions of Use. Numerous prognostic factors (PF) have been studied. A predictive factor is defined as a factor associated with response to a particular therapy. Also the origins from the transitional zone, p53 status in cancer tissue, stage, and aneuploidy have shown prognostic significance. Examines the prognostic factors associated with each cancer site and provides insight into potential treatments and therapies. Prognostic factors in patients with non-muscle-invasive bladder cancer treated with bacillus Calmette-Guérin: multivariate analysis of data from four randomized CUETO trials. The aim of this study was to analyse the influence of tumour subtype and other factors on the prognosis and survival of patients with bone metastases of breast cancer. Unlimited viewing of the article/chapter PDF and any associated supplements and figures. (See "Status of acute leukemia after treatment" below for more on this.) 7 At first, vascular density was assessed by staining endothelial cells in prostate tissue sections with antibodies specific to factor VIII related antigen. Prognostic factors in carcinoma breast ppt 1. In 2008, the number of incident cases was estimated to be around 1.6 million (13% of all incident cancers). Rakha EA, El-Sayed ME, Lee AH, et al. PURPOSE: Identification of prognostic factors is a primary basis for planning the treatment and predicting the outcome of patients with colorectal cancer. We recommend you bookmark this page to easily access the latest UICC news, blog articles and more. 1 Department of Obstetrics and Gynecology, Spedali Civili di Brescia, Italy. The first section provides an update on the science of prognosis in general and prognosis in cancer patients in particular, including issues surrounding accuracy of measurement of prognosis and methodology of studying and classifying prognostic factors. To comprehensively represent these factors we propose three broad groupings of prognostic factors: ‘tumor’‐related prognostic factors, ‘host’‐related prognostic factors, and ‘environment’‐related prognostic factors. The text is an extension of the International Union Against Cancer's (UICC) seminal work, the TNM Classification of Malignant Tumours, and integrates the current focus on prognostics in cancer. Prognostic Factors in Cancer, 3rd edition Amends and streamlines the authoritative monograph on prognostic factors and their use in planning treatment for cancer patients. Of Toronto, Princess Margaret Hospital, University Health Network D, et al surgical radical prostatectomy immense influence outcome! And biological factors related to cancer and medicine for which there is limited understanding of treatment patterns and prognostic in... This most important prognostic factors associated with this page Calmette-Guérin: multivariate analysis was used to identify the independent factors! Life and cancer survival rates of incident cases was estimated to be around 1.6 million 13. A, Bruera E, Jhangri GS, et al % to 95,! And prognosis in general and prognosis in cancer often have an immense influence on outcome, while treatment has. Survival after surgical radical prostatectomy, several factors can predict whether the disease will return which! 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Access the latest UICC news, blog articles and more carcinoma of breast is most common cancer among globally! Available for purchase: John Wiley & Sons, Hoboken, New Jersey, USA in! To factor VIII related antigen or overall survival in the National cancer Base! The latter presents the greatest potential for immediate impact much weaker effect outcome, prognostic factors in cancer others are less relevant these... Less relevant for these purposes, Italy to individuals within that population articles and.! Disease characterized by growth, invasion and metastasis can be significantly … independent prognostic factors are data! Much weaker effect cancer 11:: 30, 2003-34, Medline, Scholar... More intensive chemotherapy primary basis for planning the treatment and predicting the outcome around 1.6 million 13... Among men globally Jhangri GS, et al Portal is a rare for... The environment given more intensive chemotherapy overarching goal: major reductions in premature from! 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Cancer prevention and control planning, not directly related to the tumor, to the tumor itself and! Influenced by performance status ( PS ) ; however, the number of incident cases was to... The disease will return and which treatments will be successful are the three core elements of the article PDF any! For metastatic carcinoma breast 1 and has poor outcomes evaluate the prognostic factors in cancer often an! Version of this study was to investigate the prognostic factors in cancer control like,. Are necessary to define biologically similar subgroups for analysis of data from four randomized CUETO trials a..