The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer’s Disease Mouse Model. 2014;98(18):7661-70. Int J Mol Sci. 8. Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats. Some people find the mushroom bothers the stomach. The study noted that not all extraction methods resulted in effective extracts, however. Benefits have included lowering blood sugar, helping to reduce body fat, reducing inflammation (which can cause tissue damage), and reducing diabetic nerve pain. The fruiting body consists or an irregular, potato-sized lump covered all over with what looks like dense hair or soft spines. amzn_assoc_ad_type = "smart"; amzn_assoc_linkid = "175fb54f78591e25daf3429f298260c1"; Not only is it delicious, but (like most mushrooms) it is low in calories and has no fat; the protein content is proportionately high, but it is difficult to eat enough mushroom for it to be a major source of protein[iii]. Frontiers in Immunology. Isolation and identification of aromatic compounds in Lion’s Mane Mushroom and their anticancer activities. Accessed December 26, 2019. [27,28,29]. Any products recommended are not intended to diagnose, treat, or cure any disease. [1,2] These are two remarkable compounds that essentially stimulate the growth of new nerve tissues and brain cells. amzn_assoc_ad_mode = "manual"; Learn more about his latest project at highermindwellness.com, Justin Faerman has been studying and writing about holistic health practices, herbalism and natural medicine for over 14 years and is a leading authority on both modern and ancient therapies for creating lasting health and wellness. Improves Cognitive Function and Longevity . The mushroom grows wild across North America and Eurasia. 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One study done on mice found that consuming an extract of the mushroom reduced total cholesterol, in addition to the bad LDL variety and triglycerides, while also increasing the good HDL cholesterol. Health Benefits of Lion’s Mane. Mori K, Ouchi K, Hirasawa N. The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. 29. Int J Mol Sci. Research in humans found positive results on mental functioning in the elderly, [7] and the mushroom’s mood-boosting properties (more on that soon) help to promote a focused, calm and peaceful state of mind. amzn_assoc_tracking_id = "dmgbiz-20"; While there are more studies needed in humans to truly establish this as one of the great medicinal herbs of all time, there has been fairly extensive research in animal models that are showing some promising results. Tom Volk’s Fungus of the Month for January 2003. amzn_assoc_title = "Top Selling Mushroom Supplements"; Biomed Res. While Lion’s Mane has revealed itself as a solution for various health concerns, this mushroom has rapidly grown a reputation for its brain-health benefits and mood- and cognitive-boosting properties. Extracts and other products of the mushroom are available for sale, but have not been clinically tested for effectiveness as medicine, so there is no clear information on what safe and effective doses might be. RXList website. Here is the Best Lions Mane Supplement on the Market. Wang M, Konishi T, Gao Y, Xu D, Gao Q. Anti-Gastric Ulcer Activity of Polysaccharide Fraction Isolated from Mycelium Culture of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes). Lion’s mane mushroom may also help improve heart health, protect from inflammatory digestive issues, reduce inflammation, relieve oxidative stress, improve mental health, boost immunity and prevent diabetes. Evid Based Complement Alternat Med. The flesh is white and does not change color when sliced. Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities. Resembling a lion’s mane. It is always possible for individuals to have allergies or sensitivity. amzn_assoc_region = "US"; There have been other studies of lion’s mane as a source of anti-cancer drugs as well, but few if any clinical studies in humans and few if any studies of any anti-cancer effect of simply eating the mushroom. Learn more about his work at flowconsciousnessinstitute.com and lotussuperfoods.com. Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology. Since lion’s mane is an edible mushroom, it can generally be eaten freely. Repairs myelin sheaths Ideally, look for a full-spectrum inner and outer network product, whenever possible. Please see the references listed at the end of the article for further reading. This can be avoided by seeking US-grown products or making sure those that come from India or China are certifiably grown in rural, pollution-free areas. 2015;30(6):934-40. Effects of Atmospheric and Room Temperature Plasma (ARTP) Mutagenesis on Physicochemical Characteristics and Immune Activity In Vitro of Hericium erinaceus Polysaccharides. [35] But it’s also important to note that the cancer-fighting effects of Lion’s Mane have yet to be tested in humans, so more research is clearly needed. WebMD website. The information found on healing-mushrooms.net is strictly the author expressing an opinion. Health Benefits of Lion’s Mane Mushroom 1. lowers High Cholesterol. Furthermore, polysaccharides—microscopic healing compounds—extracted from lion’s mane mushroom also showed their own unique characteristics in an interesting study . The fungus is easy to cultivate and is often sold as pom-pom or white pom-pom. There are also a number of suspected medicinal uses. One way to measure inflammation-fighting capacity is through antioxidant activity. Pers. 2015;136:7-12. Lion’s Mane is acclaimed for its nootropic and neurotrophic abilities, working as a cognitive enhancer and supporting the growth of nervous tissue, respectively. How Lion's Mane is effective for various diseases is listed in repertory format. While lion's mane mushroom health benefits are many, the immune boosting and cancer reducing effects are common of many within the medicinal mushroom family (including chaga, reishi, and others). 7(11): 1036-1040. Accessed December 26, 2019. Names of Lion's Mane in various languages of the world are also given. Behavioral Neurology. In a hurry? Lion’s mane mushroom can help lower blood sugar and reduce diabetic nerve pain in mice, but more studies are needed to determine whether it might be … Tom Volk’s Fungi. 8. Int J Med Mushrooms. Exactly what the future of lion’s mane is in neural medicine is not yet clear but there is a lot of user based accounts that swear by it for nootropic effects, mainly improvement to focus & cognition. He sees these as the future of taking our power back into our own hands. 2011;149(2):183-92. Li Y, Zhang G, Ng TB, Wang H. A novel lectin with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from dried fruiting bodies of the monkey head mushroom Hericium erinaceum. It has been used for centuries in traditional Chinese medicine as a brain tonic and as a treatment for many health conditions. Can help reduce risk of heart disease, and other benefits.. amzn_assoc_linkid = "175fb54f78591e25daf3429f298260c1"; In keeping with its reputation as a whole-body health tonic, Lion’s Mane mushroom benefits heart health in a number of ways, in particular, by balancing cholesterol levels as well as improving circulation throughout the body. Microbial Biosystems Journal. Lion’s mane has been traditionally used to treat a variety of gastrointestinal complaints. Unfortunately, young lion’s manes may have short spines, and the young fruiting bodies of other fungi might not be branched. amzn_assoc_ad_mode = "manual"; Anticancer Potential of Hericium erinaceus Extracts Against Particular Human Cancer Cell Lines. The products recommended on healing-mushrooms.net are not verified by the FDA to treat, cure or prevent any disease. Int J Med Mushrooms. Guide to Psilocybe Cubensis (B+ Mushrooms), The Ultimate Guide to Mushroom Substrates, Growing Edible Mushrooms on Hardwood Logs, How to Make a Monotub Tek Fruiting Chamber, How to Build a DIY Shotgun Fruiting Chamber, Asian Pacific Journal of Tropical Biomedicine, Macrolepiota procera: The Parasol Mushroom Identification and Benefits, Agaricus Blazei Murrill (Subrufescens): Health Benefits & Identification. 15. Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers. amzn_assoc_tracking_id = "dmgbiz-20"; J Ethnopharmacol. Mounting evidence points to this mushroom as helping to support cognitive functioning, boost mental focus and improve memory. Accessed December 26, 2019. [3,4,5] These compounds, among others, are also thought to help protect the brain against environmental toxins and defend against the natural effects of aging. Often utilized both as culinary and medicinal food, these mushrooms can be consumed cooked, raw, dried or steeped as a tea, to be used as health supplements. 7. The Amazing Health Benefits of Lion’s Mane Mushrooms [38] Finally, it may also improve circulation by inhibiting platelet aggregation and preventing the thickening of arteries characteristic of atherosclerosis. And extracts and concentrates can also have different physical effects than whole foods; short-term testing has found various potentially medicinal substances found in lion’s mane to be non-toxic, but the effect of taking these substances long-term has not been studied. : Fr.) The products recommended in this article may have different formulations than the products used in the studies and research cited in this article. Overview. [16] The hippocampus is the area of the brain that neuroscientists believe to be responsible for regulating things like emotional stability and memory. 24. Int J Mol Sci. Lee KF, Chen JH, Teng CC, et al. It has been shown both anecdotally and in studies on mice to protect and heal the lining of the intestines from developing ulcers and generally help with inflammatory conditions of the intestines like gastritis, Chron’s disease and colitis. Phan CW, David P, Naidu M, Wong KH, Sabaratnam V. Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Since then, he has worked with doctors, scientists, and businesses such as Aloha, Evermore, Torii Labs, and Ritual.com to create natural health and wellness products. As far as dosages go, depending on the extract and source, benefits can be achieved with as little as a few hundred milligrams and can exceed up to several grams daily. 2012;34(3):504-12. Gastroprotective Effects of Lion’s Mane Mushroom Hericium erinaceus (Bull.:Fr.) (2017). 27. Int J Med Mushrooms. It is not a great source of micronutrients, but does contain some sodium, potassium, and iron. Yang BK, Park JB, Song CH. Kim YO, Lee SW, Oh CH, Rhee YH. [21], Taking a high potency extract of Lion’s Mane on a regular basis confers many health benefits, not least of which is helping to protect the gut in a number of ways. 2015;184:245-8. Uses, Benefits, Cures, Side Effects, Nutrients in Lion's Mane. This mushroom is also the closest thing that’s been found in nature to a solution to regenerate nerve cell functioning via its stimulating effects on the production of Nerve Growth Factor (NGF). [30–31] In fact, when Lion’s Mane mushroom extract is mixed with human cancer cells in a test tube, it causes the cancer cells to die at a faster rate. 2015;170:336-42. 32. 2011;32(1):67-72. 38. Aside from being rich in vitamins and minerals, Lion’s Mane also contains hericerins, erincaines, erinaceolactones, glycoproteins and polysaccharides. Lion’s mane also produces a second group of substances, the erinacines, several of which do benefit neural tissue in vitro. amzn_assoc_marketplace = "amazon"; Yet there is substantial evidence suggesting the medicinal potential of several substances produced by this species. If you’re looking for natural, non-toxin brain steroids, then you need look no further than our fungal friend Lion’s Mane. 2011;2(6):348-56. [12] Additional studies in mice have also shown that the mushroom boosts levels of acetylcholine, an essential neurotransmitter that’s important for mood and mental functioning. Effects of amycenone on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration. And while there are many things needed to accomplish that, the research emerging around the highly medicinal Lion’s Mane mushroom is showing that it actually could be a big part of the puzzle. This mushroom is known to boost the strength of the immune system, helping your body to fight off sickness and stay healthy. Immunopharmacol Immunotoxicol. 2017;97:228-237. The following purported benefits are only supported by limited, low-quality clinical studies. Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study. Promotes development of neurite bearing cells: We hope this article has shown you the remarkable characteristics and benefits of the Lion’s Mane mushroom. Lions Mane is a powerful medicinal mushroom with numerous health benefits. Zhu L, Wu D, Zhang H, et al. The two most well-known benefits of consuming lion’s mane are the potential ability to prevent or protect the spread of neurodegenerative disease and cancer. A growing body of research is showing clear links between mental illness and brain inflammation, and Lion’s Mane has been shown to reduce the production of inflammatory proteins. PLoS ONE. JAMA Neurol. Lion’s Mane (Hericium erinaceus) is a medicinal mushroom proven to benefit the brain, nerves and immune system.. 2016;17(11). More specifically, when your body releases BDNF, it flips the switch on a series of genes that grow brand new brain cells and pathways. 37. J Ethnopharmacol. Gently heat extracted to enhance bioavailability, their mushrooms are grown on their pristine farm where they can control the growing environment to enhance medicinal compounds in the product. Lion’s mane boosts immunity by relieving chronic inflammation as an antioxidant. amzn_assoc_search_bar = "true"; Further studies in rats and mice have found that Lion’s Mane also improves fat metabolism systemically. that are touted to provide all kinds of benefits for the human body. 31. Lion’s Mane benefits have been studied fairly extensively in animal models and more recently in clinical trials with humans. Food Chem. Read More. Saito T, Aoki F, Hirai H, Inagaki T, Matsunaga Y, Sakakibara T, Sakemi S, Suzuki Y, Watanabe S, Suga O, et al. 5. Int J Med Mushrooms. 10 Benefits of Lion’s Mane Mushroom There are an endless number of supplements, herbs, oils, etc. Tuszynski MH, Yang JH, Barba D, et al. Benefits have included lowering blood sugar, helping to reduce body fat, reducing inflammation (which can cause tissue damage), and reducing diabetic nerve pain. 20. Anti-hyperglycemic Property of Hericium erinaceus—A Mini Review. J Biomed Biotechnol. Other names include Monkey’s Head, Bearded Tooth, Pom Pom Blanc, Hedgehog Mushroom and Satyr’s Beard. Jiang S, Wang S, Sun Y, Zhang Q. Lion’s Mane is widely considered an effective treatment for a wide variety of neural problems. 18. Lions mane mushrooms health benefits: Enhance brain function Perhaps the most well-studied feature of the lion’s mane mushroom is its effect on brain cells and related functions. 3. It has been shown to repair damaged nerve tissue, cause regeneration of nerve fibers and also improve the communication between neurons and axons. Lion’s mane is a really unique medicinal mushroom because of its effects on the brain and nervous system. Whether there is a minimum dose necessary to derive medicinal benefits is not clear. amzn_assoc_search_bar = "true"; [11] Other compounds such as Amycenone (a patented Lion’s Mane extract) have been tested in mice and have been found in animal models to help reduce depression and anxiety. A study[ix] found that two different types of lion’s mane extract impaired the ability of colon cancer in mice to metastisize. The mushroom physically looks like the mane of lion—long, white and shaggy—with rich tentacle-like dreadlocks of mushroom wisdom bursting out from all sides. 2010;31(4):231-7. amzn_assoc_marketplace = "amazon"; Lion’s Mane Benefits, Backed by Science. The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer’s Disease Mouse Model. Lion's Mane was able to reduce LDL by 45.5% and improve HDL-C by 31.1%. Anti-inflammatory activity of mycelial extracts from medicinal mushrooms. Biomed Res. Lion’s Mane benefits have been studied fairly extensively in animal models and more recently in clinical trials with humans. Bioorg Med Chem Lett. 36. While native to all four continents, it has been only recently used amongst Western culture, although its value has been widely known and understood throughout Asia in regions like China and Japan for millennia. J Enzyme Inhib Med Chem. High levels of BDNF make you learn faster, remember better, age slower and rapidly rewire your brain. [36–37] In fact, in one of the papers, rats that were fed a high-fat diet while simultaneously being given daily doses of Lion’s Mane extract were found to have 27% lower triglyceride levels and 42% less weight gain after 28 days of the therapy. Sun Potion offers an ultra-high quality, certified organic, US-grown, full-spectrum Lion’s Mane mushroom, including the fruiting body, primordia, spores and extracellular compounds produced throughout the entire life cycle for maximum medicinal potency and effectiveness. Hypolipidemic effect of an Exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus. Biosci Biotechnol Biochem. [14–15]. Lion's mane may benefit older adults with mild cognitive impairment, according to a small study published in Phytotherapy Research in 2009. Cascadia Mushrooms website. Lion’s mane (Hericium erinaceus) is a curiously-shaped mushroom, resembling a clump of coarse, whitish hair; Star Trek fans may be strongly reminded of a tribble. As if that wasn’t enough, BDNF also increases your brain’s neuroplasticity. 33. 2015;17(7):609-18. Prior to taking ANY supplements you should consult a health care professional. Lion’s Mane is truly one of a kind. The species is edible and makes a good substitute for lobster, crab, or certain kinds of fish in some recipes (the texture is not at all hairy). It generally grows on harder surfaces rich in plant cellulose, namely trees in wooded areas. 7 Incredible Benefits of Lion's Mane Mushroom | Organic Facts He is also the Founder of Lotus Superfoods, a boutique purveyor of rare herbs and superfoods as well as the Co-founder of Conscious Lifestyle Magazine and the Flow Consciousness Institute. Here we’re talking about Lion’s Mane Mushroom and its effects on brain health and chemistry. Molecules. [vii]    Wong, J., Abdulla, M., Raman, J., Phan, C., Kuppusamy, U. R., Golbabapour, S., Sabaratnam, V. (2013). The latest science supports the traditional benefits of lion’s mane and has discovered some new ones. J Affect Disord. 6. Erinacines have also, so far, appeared non-toxic and safe to use. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. 25. [i]       Kuo, M. (2016). 30. [20], One remarkable study even found that giving mice who had been injected with a lethal dose of salmonella bacteria daily doses of Lion’s Mane extract nearly quadrupled their lifespan! It is possible to eat mycelium, but it requires processing to remove it from the substrate, and the amounts contained in the mycelium are variable and generally very small. J Antibiot (Tokyo) 1998 Nov; 51(11): 983–990. As such, they may have different effects than have been reported by these studies. 2003;67(6):1292-8. Revered in many ancient cultures and used medicinally for thousands of years, this powerhouse fungi can do everything from protect your brain against cognitive decline, boost memory, support immunity, reduce anxiety, boost mood and enhance a sense of focus throughout your day, among many other things. Abdullah N, Ismail SM, Aminudin N, Shuib AS, Lau BF. While Lion’s Mane has revealed itself as a solution for various health concerns, this mushroom has rapidly grown a reputation for its brain-health benefits and mood- and cognitive-boosting properties. For the study, researchers assigned 30 older adults with mild cognitive impairment to take either lion's mane extract or a placebo every day for 16 weeks. [17], Like many herbs and mushrooms that work in myriad ways throughout the body, one of Lion’s Mane health benefits is that it shows anti-aging effects both directly and indirectly by generally supporting overall health and well-being, as well as specifically stimulating bodily processes that are connected to slowed aging. Based on human and animal studies, this humble shroom has powerful anti-inflammatory, antioxidant and immunostimulant properties. 2014;15(9):15073-89. It causes your neural pathways to become more flexible instead of shutting down. He X, Wang X, Fang J, et al. [xi]     Hericium erinaceus. 2018;23:2515690X18765699. Used for food, healing and in spiritual ceremony, the mushroom was seen as a goddess, a harbinger of expansion, renewal and a cosmic beacon of enlightenment. Most of us would love to be smarter, happier and healthier. In cooler climates, the fungus fruits in late summer through early fall, but in warmer areas it may fruit in the winter. The inner network is generally known as the mycelium, and the outer network is known as the fruiting body. Food Funct. What’s more, is that this has been demonstrated with several types of cancer cells, including colon, stomach, blood and liver cancer cells. 2010;74(7):1447-51. Four Sigmatic offers a tasty Lion’s Mane tea extract in a convenient sachet for easy use on the go. Pers. [13], Lion’s Mane mushroom benefits may also help to alleviate anxiety and depression through its powerful effects on reducing inflammation. Brain & Cognitive Support, Stress Support. Animal models show reduction in beta-amyloid plaque [8], a major bio-indicator that this mushroom can help to restore brain health; and there is also evidence that Lion’s Mane interacts with parts of the brain’s reward circuitry, specifically kappa-opioid receptors in the brain, that are related to learning and memory. Li G, Yu K, Li F, et al. Int J Med Mushrooms. Appl Microbiol Biotechnol. 12. [22,23,24], One human study, focused on people with ulcerative colitis, found that taking a mushroom-based supplement containing 14% Lion’s Mane extract significantly reduced symptoms and improved quality of life after three weeks. R Some compounds in the mushroom, like threitol, D-arabinitol, and palmitic acid, may have antioxidant effects, regulate blood lipid levels and reduce blood glucose levels. Arch Ital Biol. (2017). (higher Basidiomycetes), in the treatment of peripheral nerve injury (review). 3. One of many other names for Lions Mane is “yamabushitake,” this translates into Mountain priest mushroom. Similarly, the mushroom may be able to slow clotting, which could also become a problem, especially in people already taking medications to slow clotting. J Agric Food Chem. Wiener CD, De mello ferreira S, Pedrotti moreira F, et al. So what exactly is so special about this superstar mushroom? Mushrooms always consist of an inner and outer network. Lion’s Mane Mushroom is one of the excellent traditional medicine to reduce levels of bad cholesterol in the body as well as increasing the good cholesterol. It is currently being tested as an experimental treatment for depression, Alzheimer’s, Multiple sclerosis and other illnesses resulting from nervous system degeneration. Whenever possible, look for USDA-certified organic Lion’s Mane products or those certifiably harvested sustainably in the wild. Serum levels of nerve growth factor (NGF) in patients with major depression disorder and suicide risk. 2015;17(11):1055-60. 2012;14(5):427-46. Lions’ Mane is also used to treat Lyme’s Disease, and digestive tract issues. Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals. To provide all kinds of benefits for the next time i comment in cooler climates, the,. Brain, nerves and immune activity in vitro, beta glucans,,... 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